Do CD4+CD25+ Immunoregulatory T Cells Hinder Tumor Immunotherapy?
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چکیده
منابع مشابه
CD4+CD25+ Immunoregulatory T Cells
CD4(+)CD25(+) immunoregulatory T cells play a pivotal role in preventing organ-specific autoimmune diseases and in tolerance induction to allogeneic organ transplants. We investigated whether these cells could also control graft-versus-host disease (GVHD), the main complication after allogeneic hematopoietic stem cell transplantation (HSCT). Here, we show that the few CD4(+)CD25(+) T cells natu...
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Objective: Autoimmune diseases will occur when the immune response inflicts damage to tissues in the body. Attempts to overcome this disease have a lot to do but they have not yielded satisfying results. In this study, the function of CD4CD25 regulatory T cells was evaluated for therapeutic potential to prevent the development of autoreactive T
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Recent publications from this laboratory (1, 2) have shown that it is possible to cause the regression of established immunogenic murine tumors by the passive transfer of tumor-sensitized T cells from immunized donors, provided the tumor-bearing recipients have been made T cell-deficient by thymectomy and irradiation. The need for T cell-deficient tumor-bearing recipients to demonstrate success...
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ژورنال
عنوان ژورنال: Journal of Immunotherapy
سال: 2002
ISSN: 1524-9557
DOI: 10.1097/00002371-200205000-00002